Download 2008-2009 Basic and Clinical Science Course: Section 9: by Ramana S. Moorthy, MD PDF

By Ramana S. Moorthy, MD

A dialogue of the medical method of uveitis ends up in broadly rewritten chapters on noninfectious (autoimmune) and infectious sorts of uveitis. additionally lined are endophthalmitis, masquerade syndromes, and issues of uveitis. A dialogue on ocular involvement in AIDS has been up to date. The part on immunology describes the human immune reaction in phrases that make it hugely obtainable to readers.

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Read or Download 2008-2009 Basic and Clinical Science Course: Section 9: Intraocular Inflammation and Uveitis (Basic and Clinical Science Course 2008-2009) PDF

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Additional info for 2008-2009 Basic and Clinical Science Course: Section 9: Intraocular Inflammation and Uveitis (Basic and Clinical Science Course 2008-2009)

Sample text

E ~~ co a: U o ca E ... o ~ u c.. - Q) II) u cou.. 0 E c o co u C).!!! Q) . Gi c ua co o... en '';:; co E E ..... t=oo .. '> .. 0. cQ) E E u'-co .... ) I"""U Q) Q) Q) Q) o... 5::! § -o .. ~ o u.. "'. "'. ;: CO c. J U c.. E .!!! Qj U C> c 'E Q) II) Q) c. ~ c co II U c.. <{ CHAPTER 3: Ocular Immune 33 Responses. and important. Chapter 4 discusses these mechanisms in greater detail. See also Part IV of BCSC Section 8, External Disease and Cornea.

In addition, some LCs leave the skin, enter the draining node, and encounter memory T lymphocytes there. Processing during the secondary response is much quicker, and within 24 hours restimulated memory cells enter the circulation and migrate to the 29 30 . Intraocular Inflammation and Uveitis toxin-exposed cutaneous site. Because abundant toxin remains, additional T Iymphocyte-LC stimulation occurs, inducing vigorous T-Iymphocyte cytokine production. The inflammatory mediators, in turn, recruit neutrophils and monocytes, leading to a severe inflammatory reaction within 12-36 hours after exposure, causing the typical epidermal blisters of poison ivy.

Nevertheless, low numbers of plasma macromolecules bypass the nonpigmented epithelium barrier and may permeate by diffusion anteriorly through the uvea to enter the anterior chamber through the anterior iris surface. The inner eye does not contain well-developed lymphatics. Rather, clearance of soluble substances depends on the aqueous humor outflow channels; clearance of particulates depends on endocytosis by trabecular meshwork endothelial cells or macrophages. Nevertheless, antigen inoculation into the anterior chamber results in efficient communication with the systemic immune response.

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