By Anthony J. Hickey, Timothy M. Crowder, Margaret D. Louey, Norman Orr
Exploring the expansion in wisdom of particle houses and the diversity of technological advances in particle manufacture, this publication offers readers the instruments they should comprehend particulate technological know-how and its use within the undefined. The authors hide particulate fabric, its shape and creation, sampling from our bodies of powder, particle dimension descriptors and statistics, habit of debris, instrumental research, particle measurement size and synergy of followed innovations, actual habit of a powder, and in vitro and in vivo functionality standards. They draw the elements of particulate technological know-how right into a unmarried concise description in their integration within the context of product improvement.
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Extra resources for A Guide to Pharmaceutical Particulate Science
J. Pharm. 124:149–164. Zeng, X. , G. P. -K. Tee, and C. Marriott. 1998. The role of fine particle lactose on the dispersion and deaggregation of salbutamol sulphate in an air stream in vitro. Int. J. Pharm. 176:99–110. Zeng, X. , G. P. -K. Tee, A. A. Ghoush, and C. Marriott. 1999. Effects of particle size and adding sequence of fine lactose on the deposition of salbutamol sulphate from a dry powder formulation. Int. J. Pharm. 182:133–144. Zeng, X. , K. H. Pandal, and G. P. Martin. 2000. The influence of lactose carrier on the content homogeniety and dispersibility of beclomethasone dipropionate from dry powder aerosols.
Staniforth, J. N. 1987. Order out of chaos. J. Pharmacy Pharmacol. 39:329–334. Staniforth, J. N. 1988. Powder flow. In Pharmaceutics: The science of dosage form design, ed. M. E. Aulton. New York: Churchill Livingstone. 600–615. Staniforth, J. N. 1996. Improvements in dry powder inhaler performance: Surface passivation effects. Drug Deliv. Lungs 7: 86–89. Staniforth, J. , and J. E. Rees. 1982a. Effect of vibration time, frequency and acceleration on drug content uniformity. J. Pharmacy Pharmacol.
Modern techniques of X-ray crytallography enable lattice dimensions and interfacial angles to be measured, by the application of Bragg’s law, with high precision on milligram quantities of crystalline powders (Nuffield 1966; Llacer et al. 2001; Darcy and Buckton 1998; Brittain 2001). Crystal Symmetry Classification of crystals can be considered in terms of the apparent order conveyed visually. This can be described in terms of the symmetries exhibited, either about a point (center), a line (axis), or a plane.