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Second, since these animals are being autopsied more carefully in the search for metastases or for drug effects on xenografted tumours than is sometimes the case in other animal tumour experiments, there is a possibility that unfamiliarity with the normal tissue appearances in health and disease may lead to errors of interpretation. One good illustration of the need for routine naked-eye and histological examination of nude mice is the fact that it took 2 years for it to become known that the nude mouse was athyrnic (Pantelouris, 1968).

Exp. , 96, 293-302. , Tamaoki, N. and Fujiwara, K. Proceedings of the Second International Workshop on Nude Mice, University of Tokyo Press, Tokyo and Gustav Fischer Verlag, Stuttgart Outzen, H. , Custer, R. , Eaton, G. H. and Prehn, R. T. (1975). Spontaneous and induced tumour incidence in germ-free 'nude' mice. J. reticuloendothel. , 17, 1-9 Pantelouris, E. M. (1968). Absence of thymus in nude mouse mutaat. , Isaak, D. D. and Jacobson, R. H. (1977). The use of nude mice in model systems for studies on acquired immunity to parasitic infections.

J. , 115,462-5 Silverman, D. A. and Rose, N. R. (1975). Spontaneous and methylcholanthrene-enhanced thyroiditis in BUF rats. I. J. , 114,145-7 Simpson, L. 0. (1976). An NZB virus or NZB mice with viral infections? Lab. Animals, 10, 249-60 Staats, J. (1976). Standardized nomenclature for inbred strains of mice: sixth listing. , 36,4333-77 Stutman, 0. (1974). Tumour development in immunologically deficient nude mice after exposure to chemical carcinogens. In Proceedings of the First International Workshop on Nude Mice (J.

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