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T h e site of origin of most carcinomas is the TDLU (Azzopardi, 1979). It seems likely that many, if not all, invasive breast carcinomas (Fig. 1C) are preceded by a carcinoma in situ (Fig. lB), which originates in the TDLU. Two major forms of carcinoma in situ are recognized: lobular carcinoma in situ (LCIS) and ductal carcinoma in situ (DCIS). Carcinoma in situ represents a malignant epithelial cell proliferation confined to the epithelial compartment of preexisting ducts and lobules, without evidence of invasive growth.