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By Paul L. Munson, John Glover, Egon Diczfalusy and Robert E. Olson (Eds.)

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A m . Chern. 102, 1436-1439. , and Jacklin, A. G. (1957). J. Chem. Soc. 1632-1646. Dahlen, S. , and Samuelsson, B. (1980). Leukotrienes are potent constrictors of human bronchi. Nature (London) 288, 484-486. Dahlen, S. , and Samuelsson, B. (1981). Importance of cysteinyl-substituent for leukotriene broncho-constrictor potency. Proc. Natl. A cad. Sci. A. 78, 3887-3891. Dahlen, S . , and Hammarstrom, S. (1982). Eur. , in press. Doig, M. , and Ford-Hutchinson, A. W. (1980). Prostaglandins 20, 1007-1019.

The effect of triethylamine sulfate was originally thought to be due to formation of triethylammonium salts of the steroid sulfates. However, the mechanism is probably much more complex, as seen from the study of Rotsch and Pietrzyk (1980). Formation of electrical double layers, ion exchange, and ion-pair formation may all be involved. More recent studies indicate that Amberlite XAD-2 has ionic sites with high a f i i t y for sulfate anions (Axelson and 38 JAN SJOVALL AND MAGNUS AXELSON Sahlberg, 1981).

Brashler, J. , and Samuelsson, B. (1980a). Identification of leukotriene C-1 as a major component of slow reacting substance from rat mononuclear cells. J . Zmmunol. 125, 115-117. Bach, M. , Brashler, J. , and Samuelsson, B. (1980b). Identification of a component of rat mononuclear cell SRS as leukotriene D. Bzochem. Biophys. Res. Commun. 93, 1121-1126. , and Hammarstrom, S. (1981). Metabolism of leukotriene D by porcine kidney. J . Biol. Chem. 256, 9579-9582. 28 B. SAMUELSSON AND S. , and Samuelsson, B.

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