Download Advances in Vascular Medicine by Ioannis Papaioannou, James S. Owen (auth.), David Abraham, PDF

By Ioannis Papaioannou, James S. Owen (auth.), David Abraham, Handler Clive, Michael Dashwood, Gerry Coghlan (eds.)

Understanding the various complicated mobile and molecular mechanisms underlying human vascular illnesses is key in enhancing the administration of sufferers with this clinically vital and wide-ranging staff of ailments. this can be really vital while contemplating the level of this factor around the world.

Written by way of a crew of world-renowned gurus, Advances in Vascular Medicine highlights a few of the relationships among uncomplicated technological know-how and medical medication, and reports either learn and scientific perform tools and results in vascular biology and pathobiology. it's an authoritative reference for those vital themes of vascular biology and contains chapters that designate the medical matters to the elemental scientist in addition to offering clinicians with a systematic grounding in vascular ailments. even if there's nonetheless a lot paintings to be performed to strengthen realizing of vascular affliction, the data and insights contained during this booklet are an important contribution to the literature, giving scientists and clinicians the chance to profit extra approximately this interesting box of biomedicine.

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Notably, by regulation of appropriate splicing factors, this mechanism termed alternative splicing allows different cell types to produce distinct product(s) from a particular gene. (b) Splice site selection can be blocked artificially using antisense oligonucleotides (ASO), for example (as shown) by targeting an exonic splicing enhancer (ESE) or silencer (ESS) element. 40 Although RNA interference successfully reduced plasma LDL, it is uncertain whether impaired production of chylomicrons might cause liver toxicity and intestinal dysfunction as is sometimes observed in FHBL patients.

2007;104:3055–3060. Chapter 2 Gene Delivery to Cardiovascular Tissue Rachel Masson, Stuart A. Nicklin, and Andrew H. Baker Abbreviations AAV Ad CABG CAR CVD EC eNOS FGF FGFR1 FH HIV HO-1 HSPG HSV iNOS ITR LDL LDLR MMPs nNOS NO Adeno-associated virus Adenovirus Coronary artery bypass graft Coxsackie virus and adenovirus receptor Cardiovascular disease Endothelial cells Endothelial nitric oxide synthase Fibroblast growth factor Fibroblast growth factor receptor-1 Familial hypercholesterolemia Human immunodeficiency virus Heme oxygenase-1 Heparan sulfate proteoglycans Herpes simplex virus Inducible nitric oxide synthase Inverted terminal repeats Low-density lipoprotein Low-density lipoprotein receptor Matrix metalloproteinases Neuronal nitric oxide synthase Nitric oxide R.

RNA. 2007;13:1609–1624. 32. Parekh-Olmedo H, Kmiec EB. Progress and prospects: targeted gene alteration (TGA). Gene Ther. 2007;14:1675–1680. 22 I. S. Owen 33. Soutschek J, Akinc A, Bramlage B, et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature. 2004;432:173–178. 34. Zimmermann TS, Lee AC, Akinc A, et al. RNAi-mediated gene silencing in non-human primates. Nature. 2006;441:111–114. 35. Frank-Kamenetsky M, Grefhorst A, Anderson NN, et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates.

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