By Munenori Takehara, Hideo Hirohara (auth.), Yoshimitsu Hamano (eds.)
Microorganisms are able to generating a large choice of biopolymers. Homopolymer peptides, that are made from just a unmarried kind of amino acid, are a long way much less ubiquitous. the one amino-acid homopolymers identified to take place in nature are offered during this quantity. Poly-epsilon-L-lysine is a polycationic peptide and shows antimicrobial job opposed to a large spectrum of microorganisms. it's either secure and biodegradable and is for this reason used as a foodstuff preservative in numerous nations. moreover, there was nice curiosity in scientific and different purposes of poly-lysine and its derivatives. by contrast, poly-gamma-glutamic acid is an strange anionic polypeptide. it's also water soluble, biodegradable, suitable for eating, non-toxic and non-immunogenic and will be chemically transformed to introduce quite a few medicinal drugs. those beneficial properties are very valuable for pharmaceutical and biomedical functions. Poly-glutamic acid can also be a hugely beautiful as nutrients ingredient.
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Extra info for Amino-Acid Homopolymers Occurring in Nature
Agric Biol Chem 41:1807–1809 Shima S, Sakai H (1981a) Poly-L-lysine produced by Streptomyces. II. Taxonomy and fermentation studies. Agric Biol Chem 45:2497–2502 Shima S, Sakai H (1981b) Poly-L-lysine produced by Streptomyces. III. Chemical studies. Agric Biol Chem 45:2503–2508 Shima S, Matsuoka H, Sakai H (1982) Inactivation of bacteriophages by e-poly-L-lysine produced by Streptomyces. Agric Biol Chem 46:1917–1919 Shima S, Oshima S, Sakai H (1983) Biosynthesis of e-poly-L-lysine by washed mycelium of Streptomyces albulus No.
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5 Substrate Specificity of Pls . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 4 Concluding Remarks and Future Perspectives . . . . . . . . . . . . . . . . . . . . . . . 38 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 Abstract Streptomyces albulus NBRC14147 (previously named IFO14147) is known to produce the amino-acid homopolymer antibiotic, poly-e-L-lysine (e-polyL-lysine, e-PL), consisting of 25–35 L-lysine residues with a linkage between the a-carboxyl group and the e-amino group.